Title : Acute effect of ethanol on renal electrolyte transport in the rat.

Pub. Date : 1995 Sep

PMID : 8542675






5 Functional Relationships(s)
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1 The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release. Ethanol arginine vasopressin Rattus norvegicus
2 The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release. Ethanol arginine vasopressin Rattus norvegicus
3 However, the antidiuretic effect of a submaximal concentration of AVP (7.5 ng/kg) was augmented by ethanol at concentrations of 1.63 and 0.98 mmol/L. Ethanol arginine vasopressin Rattus norvegicus
4 These studies suggest that the ethanol induced diuresis commonly ascribed to inhibition of AVP secretion may also be due to other intrarenal effects of ethanol, possibly acting within the proximal tubule. Ethanol arginine vasopressin Rattus norvegicus
5 These results also confirm recent in vitro findings that while ethanol does not inhibit the action of a maximal concentration of AVP, it does modulate the effects of lower AVP concentrations. Ethanol arginine vasopressin Rattus norvegicus