Title : Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism.

Pub. Date : 1993 Mar 24

PMID : 8466547






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SMX was acetylated by both NAT1 and NAT2. Sulfamethoxazole N-acetyltransferase 2 Homo sapiens
2 Km values determined in hepatic cytosol for NAT1- and NAT2-mediated acetylation of SMX were 1.2 mM and approximately 5 mM, respectively, at an acetyl coenzyme A concentration of 100 microM. Sulfamethoxazole N-acetyltransferase 2 Homo sapiens
3 However, in the hepatocyte NAT2 variation may be an important competitive pathway which influences the extent of oxidative metabolism of SMX to its reactive hydroxylamine metabolite. Sulfamethoxazole N-acetyltransferase 2 Homo sapiens