Title : Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

Pub. Date : 1993 Jun 15

PMID : 8390534






3 Functional Relationships(s)
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1 We demonstrate that PGE2 selectively and dose dependently inhibits IL-2 and IFN-gamma production by mitogenically stimulated human PBL and CD4+ TLC, although at low concentrations IL-4 production is not affected and IL-5 production is even up-regulated. Dinoprostone interleukin 2 Homo sapiens
2 The action of PGE2 may, therefore, be associated with elevation of intracellular cAMP levels, affecting IL-4 and IL-5 differentially from IL-2 and IFN-gamma production. Dinoprostone interleukin 2 Homo sapiens
3 Similar to PGE2, forskolin, 2"-O-dibutyrylcAMP, and 3-isobutyl-1-methyl-xanthine induced inhibition of IL-2 production by TLC and up-regulation of IL-5 production. Dinoprostone interleukin 2 Homo sapiens