Title : Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionyl-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation.

Pub. Date : 1994 Mar 15

PMID : 8147901






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 SC-45662 inhibited superoxide generation induced by fMLP and C5a with IC50 values of 12 and 5 microM, respectively. Superoxides complement C5a receptor 1 Homo sapiens
2 Furthermore, SC-45662 was capable of inhibiting fMLP and C5a induced superoxide release in PMNs primed with bacterial lipopolysaccharide, tumor necrosis factor-alpha and other priming agents. Superoxides complement C5a receptor 1 Homo sapiens
3 SC-41661A, a compound from the same chemical series as SC-45662, did not inhibit or induce superoxide generation, but instead primed PMNs for fMLP and C5a induced superoxide generation. Superoxides complement C5a receptor 1 Homo sapiens