Title : Hematopoietic progenitor cells of transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to tumor necrosis factor.

Pub. Date : 1994 Aug

PMID : 8040183






4 Functional Relationships(s)
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1 Since recent data strongly suggested that generation of superoxide is a key step in cytotoxicity of TNF, we reasoned that cells expressing high levels of enzymes that degrade superoxide radicals would be resistant to TNF. Superoxides tumor necrosis factor Mus musculus
2 Since recent data strongly suggested that generation of superoxide is a key step in cytotoxicity of TNF, we reasoned that cells expressing high levels of enzymes that degrade superoxide radicals would be resistant to TNF. Superoxides tumor necrosis factor Mus musculus
3 Since recent data strongly suggested that generation of superoxide is a key step in cytotoxicity of TNF, we reasoned that cells expressing high levels of enzymes that degrade superoxide radicals would be resistant to TNF. Superoxides tumor necrosis factor Mus musculus
4 These results suggest that the mechanism of TNF-mediated growth inhibition of hematopoietic cells occurs through production of superoxide. Superoxides tumor necrosis factor Mus musculus