Pub. Date : 1994 Nov
PMID : 7931322
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phorbol ester- and retinoic acid-induced regulation of the protein kinase C substrate MARCKS in immortalized hippocampal cells. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 2 | The expression of MARCKS, a major protein kinase C (PKC) substrate, was examined in the immortalized hippocampal cell line HN33, following differentiation using phorbol esters or retinoic acid. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 3 | MARCKS protein expression was also down-regulated in a dose-dependent manner on exposure of HN33 cells to retinoic acid. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 4 | In cells exposed to 10 microM retinoic acid, the MARCKS protein level was reduced in the membrane fraction within 4 h. Reduction of MARCKS protein levels was maximal (> 90%) by 12 h with no evidence for any alteration in PKC activity. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 5 | In cells exposed to 10 microM retinoic acid, the MARCKS protein level was reduced in the membrane fraction within 4 h. Reduction of MARCKS protein levels was maximal (> 90%) by 12 h with no evidence for any alteration in PKC activity. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 6 | Reduced levels of MARCKS protein were also observed in the soluble fraction of retinoic acid-exposed cells, but to a significantly lesser extent. | Tretinoin | myristoylated alanine rich protein kinase C substrate | Homo sapiens |