Title : Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

Pub. Date : 1995 Nov 15

PMID : 7594459






5 Functional Relationships(s)
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1 Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5. Dinoprostone interleukin 2 Homo sapiens
2 PGE2 added at priming of naive T cells inhibited the production of IL-2 and IFN-gamma, but not of IL-4 and IL-5, in a dose-dependent manner. Dinoprostone interleukin 2 Homo sapiens
3 This change in the cytokine production profile induced by PGE2 was maintained in T cells restimulated with anti-CD3 in the absence of PGE2, expanded by IL-2, and stimulated with PMA and ionomycin. Dinoprostone interleukin 2 Homo sapiens
4 PGE2 must exist at an early stage of T cell activation to inhibit priming for IL-2 and IFN-gamma production. Dinoprostone interleukin 2 Homo sapiens
5 These results indicate that PGE2 inhibits the acquisition of the ability to produce IL-2 and IFN-gamma by acting directly on naive T cells. Dinoprostone interleukin 2 Homo sapiens