Title : cAMP regulates gastrin gene expression.

Pub. Date : 1995 Sep

PMID : 7573458






4 Functional Relationships(s)
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1 cAMP regulates gastrin gene expression. Cyclic AMP gastrin Homo sapiens
2 Since various luminal and humoral factors stimulate the production of cAMP and gastrin secretion in both gastrinoma and antral G cells, we studied the effect of cAMP on gastrin gene expression. Cyclic AMP gastrin Homo sapiens
3 Using stable and transient transformants of a pituitary cell line containing the human gastrin gene, we found that cAMP stimulates a three-fold increase in gastrin mRNA levels and that the response maps to elements located between -148 and -40 base pairs upstream from the cap site. Cyclic AMP gastrin Homo sapiens
4 Using stable and transient transformants of a pituitary cell line containing the human gastrin gene, we found that cAMP stimulates a three-fold increase in gastrin mRNA levels and that the response maps to elements located between -148 and -40 base pairs upstream from the cap site. Cyclic AMP gastrin Homo sapiens