Title : Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.

Pub. Date : 1995 Oct 1

PMID : 7557387






2 Functional Relationships(s)
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1 Induction of C/EBP beta DNA-binding activity in NIH-3T3 beta 2 cells exposed to dexamethasone in the presence of insulin and fetal bovine serum activates the expression of an adipocyte-specific nuclear hormone receptor, PPAR gamma, that stimulates the conversion of these fibroblasts into committed preadipocytes. Dexamethasone peroxisome proliferator activated receptor gamma Mus musculus
2 Either ectopic expression of C/EBP beta or treatment with dexamethasone alone is incapable of inducing PPAR gamma expression, but when present together, they have a synergistic effect on the adipogenic program. Dexamethasone peroxisome proliferator activated receptor gamma Mus musculus