Title : Estrogen in high doses inhibits perphenazine-induced prolactin release.

Pub. Date : 1982 Jan

PMID : 7053978






3 Functional Relationships(s)
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1 Daily administration of 0.1 micrograms estradiol benzoate to female mice for 4 weeks significantly increased the amplitude of PRL release induced by perphenazine. estradiol 3-benzoate prolactin Mus musculus
2 The rise in basal serum PRL concentrations seen at lower doses of estradiol benzoate was also minimized with 20- and 50-micrigrams doses. estradiol 3-benzoate prolactin Mus musculus
3 At the same time, PRL concentrations within the pituitary gland as well as pituitary weight consistently increased in response to all high doses of estradiol benzoate tested, although the increment at the highest dose (50 micrograms) was somewhat smaller. estradiol 3-benzoate prolactin Mus musculus