Title : [Utilization of melanin precursors for experimental chemotherapy of malignant melanoma].

Pub. Date : 1984 Oct

PMID : 6435538






2 Functional Relationships(s)
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1 Our studies indicated (a) that hydroquinone and 4-isopropylcatechol are selectively toxic to melanocytes and melanoma cells, (b) that their actions are mediated through tyrosinase, and (c) that dopa is selectively and highly incorporated into melanoma cells and melanocytes depending on the tyrosinase activity. hydroquinone tyrosinase Mus musculus
2 Our studies indicated (a) that hydroquinone and 4-isopropylcatechol are selectively toxic to melanocytes and melanoma cells, (b) that their actions are mediated through tyrosinase, and (c) that dopa is selectively and highly incorporated into melanoma cells and melanocytes depending on the tyrosinase activity. hydroquinone tyrosinase Mus musculus