Title : Bromocriptine suppresses ACTH secretion from human pituitary tumour cells in culture by a dopaminergic mechanism.

Pub. Date : 1981 Nov

PMID : 6276051






3 Functional Relationships(s)
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1 Bromocriptine suppresses ACTH secretion from human pituitary tumour cells in culture by a dopaminergic mechanism. Bromocriptine proopiomelanocortin Homo sapiens
2 Bromocriptine (0.13-13 microM) significantly inhibited ACTH secretion in a dose-dependent manner when added to cell cultures of a human corticotrophic adenoma for 24 h. Haloperidol (13 microM), but not serotonin (13 microM), blocked this inhibition but had no significant effect when added alone. Bromocriptine proopiomelanocortin Homo sapiens
3 An ectopic ACTH secreting lung carcinoid was non-responsive to doses of bromocriptine up to 13 microM. Bromocriptine proopiomelanocortin Homo sapiens