Title : Multistage functional system amplifying and spreading the effect of estradiol in rat uterus.

Pub. Date : 1980 Feb 28

PMID : 6246414






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Estradiol is demonstrated to induce histidine decarboxylase, and histamine is shown to activate adenylate cyclase in rat uterus. Estradiol histidine decarboxylase Rattus norvegicus
2 The data suggest that estradiol enhances by induction of histidine decarboxylase the formation of histamine, the latter activates adenylate cyclase providing accumulation of cyclic 3",5"-AMP, which, probably, induces glycolytic enzymes through phosphorylation of chromatin proteins, and mediates other estradiol effects. Estradiol histidine decarboxylase Rattus norvegicus