Title : Effect of intragastric amino acids on lower esophageal sphincter pressure and serum gastrin in man.

Pub. Date : 1986 Mar

PMID : 3953532

2 Functional Relationships(s)
Compound Name
Protein Name
1 Only phenylalanine and tryptophan produced significant stimulation of serum gastrin levels with peak increases above basal occurring 30 min after administration (p less than 0.05). Tryptophan gastrin Homo sapiens
2 It is concluded that: aspartic acid, leucine and glycine produced no significant changes in LES pressure or serum gastrin level; tryptophan and phenylalanine significantly increased serum gastrin concentration; tryptophan significantly decreased LES pressure whereas phenylalanine had no effect; the mechanism of inhibition of LES pressure by tryptophan is not defined and may be mediated by neural or hormonal pathways possibly involving a duodenal receptor. Tryptophan gastrin Homo sapiens