Title : Isolation of variants resistant to methylglyoxal bis(guanylhydrazone) from adenovirus-transformed rat cells.

Pub. Date : 1987 Mar 1

PMID : 3815342






1 Functional Relationships(s)
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1 Two variant clones (G1 and G2) were isolated and characterized: they were 5-fold more resistant to methylglyoxal bis(guanylhydrazone); they had a stable phenotype; they showed decreased drug uptake; they had a reduced ability to grow in soft agar, low serum, and nude mice; there was no detectable change in the restriction pattern of integrated viral genes or in the expression of the E1a and E1b proteins. Mitoguazone NADH:ubiquinone oxidoreductase subunit C2 Mus musculus