Title : Nicotine-induced release of vasopressin in the conscious rat: role of opioid peptides and hemodynamic effects.

Pub. Date : 1987 Nov

PMID : 3681699






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1 Nicotine-induced release of vasopressin in the conscious rat: role of opioid peptides and hemodynamic effects. Nicotine arginine vasopressin Rattus norvegicus
2 Nicotine has been shown to stimulate the release of vasopressin and to cause significant hemodynamic changes. Nicotine arginine vasopressin Rattus norvegicus
3 The mechanisms leading to enhanced vasopressin secretion and the vascular consequences of the high plasma vasopressin levels during nicotine infusion have not yet been determined. Nicotine arginine vasopressin Rattus norvegicus
4 Therefore, the purposes of the present study were 1) to examine in normal conscious rats the role of opioid peptides in the nicotine-induced increase in plasma vasopressin levels and 2) to assess the role of vasopressin in the hemodynamic effects of nicotine (20 micrograms/min for 15 min) using a specific V1 antagonist of the vascular actions of vasopressin. Nicotine arginine vasopressin Rattus norvegicus
5 Plasma vasopressin levels were significantly increased in the nicotine-treated animals (39.5 +/- 10 vs. 3.7 +/- 0.6 pg/ml in the controls, P less than .01). Nicotine arginine vasopressin Rattus norvegicus
6 Thus, these results suggest that the nicotine-induced secretion of vasopressin is not mediated by opioid receptors and that the high plasma vasopressin levels do not exert any significant hemodynamic effect on cardiac output or blood flow distribution. Nicotine arginine vasopressin Rattus norvegicus