Title : Aggregation of a Parkinson's Disease-Related Peptide: When Does Urea Weaken Hydrophobic Interactions?

Pub. Date : 2022 Jun 15

PMID : 35616516






1 Functional Relationships(s)
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1 Here, we study, through molecular simulations, the hydration and binding free energies of an amphiphilic peptide from the nonamyloid-beta component (NAC), a key aggregation-prone domain of alpha-synuclein, in water and an 8 M aqueous urea solution. Water synuclein alpha Homo sapiens