Title : In utero bisphenol AF exposure causes fetal Leydig cell dysfunction and induces multinucleated gonocytes by generating oxidative stress and reducing the SIRT1/PGC1α signals.

Pub. Date : 2022 Jul 15

PMID : 35605789






2 Functional Relationships(s)
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1 Furthermore, BPAF markedly reduced the levels of SIRT1 and PGC1alpha at 200 mg/kg/d while significantly increased AMPK phosphorylation in the testes at 50 and 200 mg/kg/d. 4,4'-hexafluorisopropylidene diphenol sirtuin 1 Rattus norvegicus
2 In conclusion, our results provide novel in vivo data that BPAF can induce fetal Leydig cell dysfunction by interfering with steroidogenic networks and induce the formation of multinucleated gonocytes after suppressing the antioxidant defense system and reducing SIRT1 and PGC1alpha signals and increasing the phosphorylation of AMPK, which highlights the potential health risk of environmental exposure to BPAF in inducing male reproductive tract malformation. 4,4'-hexafluorisopropylidene diphenol sirtuin 1 Rattus norvegicus