Title : The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.

Pub. Date : 2022 May 10

PMID : 35545049






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Here we show that tumor-secreted lactate downregulates p62 transcriptionally through a mechanism involving reduction of the NAD+/NADH ratio, which impairs poly(ADP-ribose)-polymerase 1 (PARP-1) activity. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 Here we show that tumor-secreted lactate downregulates p62 transcriptionally through a mechanism involving reduction of the NAD+/NADH ratio, which impairs poly(ADP-ribose)-polymerase 1 (PARP-1) activity. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
3 Here we show that tumor-secreted lactate downregulates p62 transcriptionally through a mechanism involving reduction of the NAD+/NADH ratio, which impairs poly(ADP-ribose)-polymerase 1 (PARP-1) activity. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
4 Here we show that tumor-secreted lactate downregulates p62 transcriptionally through a mechanism involving reduction of the NAD+/NADH ratio, which impairs poly(ADP-ribose)-polymerase 1 (PARP-1) activity. NAD poly(ADP-ribose) polymerase 1 Homo sapiens