Title : Extracellular cAMP-Adenosine Pathway Signaling: A Potential Therapeutic Target in Chronic Inflammatory Airway Diseases.

Pub. Date : 2022

PMID : 35479074






3 Functional Relationships(s)
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1 In airways, beta2-adrenoceptor agonists, which are used as bronchodilators for treatment of asthma and chronic respiratory diseases, stimulate cAMP efflux and thus trigger the extracellular cAMP-adenosine pathway leading to increased concentrations of extracellular adenosine in airways. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 In airways, beta2-adrenoceptor agonists, which are used as bronchodilators for treatment of asthma and chronic respiratory diseases, stimulate cAMP efflux and thus trigger the extracellular cAMP-adenosine pathway leading to increased concentrations of extracellular adenosine in airways. Cyclic AMP adrenoceptor beta 2 Homo sapiens
3 These considerations lead to the hypothesis that the cAMP-adenosine pathway attenuates the efficacy of beta2-adrenoceptor agonists. Cyclic AMP adrenoceptor beta 2 Homo sapiens