Title : Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis.

Pub. Date : 2022 May

PMID : 35461327






2 Functional Relationships(s)
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1 We also found that chronic nicotine exposure recruited STAT3-activated N2-neutrophils within the brain pre-metastatic niche and secreted exosomal miR-4466 which promoted stemness and metabolic switching via SKI/SOX2/CPT1A axis in the tumor cells in the brain thereby enabling metastasis. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 We also demonstrated that inhibiting nicotine-induced STAT3-mediated neutrophil polarization effectively abrogated brain metastasis in vivo. Nicotine signal transducer and activator of transcription 3 Homo sapiens