Title : [CD36 gene deletion reduces muscle insulin sensitivity in mice by up-regulating PTP1B expression].

Pub. Date : 2022 Mar 20

PMID : 35426803






2 Functional Relationships(s)
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1 Tyrosine phosphorylation of IR and IRS1 and histone acetylation of PTP1B promoter in muscle tissues were detected using co-immunoprecipitation (Co-IP) and chromatin immunoprecipitation (ChIP), respectively. Tyrosine insulin receptor substrate 1 Mus musculus
2 In the muscle tissue of CD36-/- mice, tyrosine phosphorylation levels of IR and IRS1 were significantly decreased (P < 0.05), and the mRNA and protein levels of PTP1B (P < 0.05) and histone acetylation level of PTP1B promoters (P < 0.01) were significantly increased as compared with those in the WT mice. Tyrosine insulin receptor substrate 1 Mus musculus