Title : Cardio-respiratory and phenotypic rescue of dystrophin/utrophin-deficient mice by combination therapy.

Pub. Date : 2022 Jun 7

PMID : 35393769






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we demonstrate that the combination of oral glycine and metformin with intravenous PMO enhances PMO activity, dystrophin restoration, extends lifespan, and improves body-wide function and phenotypic rescue of dystrophin /utrophin double knock-out (DKO) mice without any overt adverse effects. Glycine dystrophin, muscular dystrophy Mus musculus
2 Here, we demonstrate that the combination of oral glycine and metformin with intravenous PMO enhances PMO activity, dystrophin restoration, extends lifespan, and improves body-wide function and phenotypic rescue of dystrophin /utrophin double knock-out (DKO) mice without any overt adverse effects. Glycine dystrophin, muscular dystrophy Mus musculus