Title : D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes.

Pub. Date : 2022 Apr

PMID : 35385545






3 Functional Relationships(s)
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1 D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytes. Dinoprostone surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 The DD-induced PGE2 and inflammatory cytokines were enhanced significantly by co-treatment with immune complexes (IC) of SARS CoV2 recombinant S protein or of pseudovirus containing SARS CoV-2 S protein (PVCoV2) coated with spike-specific chimeric monoclonal antibody (MAb) containing mouse variable and human Fc regions. Dinoprostone surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 PGE2 and IL-6/IL-8 cytokines produced in monocytes activated with plasma-containing IC, correlated well with the levels of spike binding antibodies and not with neutralizing antibody titers. Dinoprostone surface glycoprotein Severe acute respiratory syndrome coronavirus 2