Pub. Date : 2022 Apr 2
PMID : 35366176
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-kappaB and upregulating PPAR-gamma signal. | diacerein | toll-like receptor 4 | Rattus norvegicus |
| 2 | Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression. | diacerein | toll-like receptor 4 | Rattus norvegicus |
| 3 | Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression. | diacerein | toll-like receptor 4 | Rattus norvegicus |
| 4 | CONCLUSIONS: This study demonstrated that DIA exerts anti-apoptotic, anti-inflammatory, and antioxidant properties against liver injury induced by APAP that is attributed to inhibition of the HMGB1/TLR4/NF-kappaB pathway, besides upregulation of the expression of PPAR-gamma. | diacerein | toll-like receptor 4 | Rattus norvegicus |