Title : Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase.

Pub. Date : 2022 May

PMID : 35266648






1 Functional Relationships(s)
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1 Melanogenesis (melanin pigment production) in melanocytes is canonically stimulated by the alpha melanocyte stimulating hormone (alphaMSH), which activates the cyclic-AMP-mediated expression of the melanocyte inducing transcription factor (MITF) and its downstream melanogenic genes, including the principal rate-limiting melanogenic enzyme tyrosinase (TYR). Cyclic AMP proopiomelanocortin Homo sapiens