Title : Classic and current concepts in adrenal steroidogenesis: a reappraisal.

Pub. Date : 2022 Mar 8

PMID : 35263051






2 Functional Relationships(s)
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1 We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies. Desoxycorticosterone proopiomelanocortin Homo sapiens
2 We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies. Desoxycorticosterone proopiomelanocortin Homo sapiens