Title : Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells.

Pub. Date : 2022

PMID : 35178160






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1 This study firstly verified the PAOX upregulation in human degenerated disc samples and applied an IL-1beta-induced nucleus pulposus (NP) cell degeneration model to demonstrate that spermidine supplementation balanced polyamine metabolism and delayed NP cell senescence. Spermidine interleukin 1 alpha Homo sapiens