Title : A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression.

Pub. Date : 2021

PMID : 35126177






3 Functional Relationships(s)
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1 MpkCCD cells expressed mRNAs for the receptors of PGE2 (EP1/EP4), PGF2 (FP), and TxB2 (TP). Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
2 Moreover, in the presence of dDAVP, an EP1/3, but not EP4, agonist decreased the AQP2 abundance, and the addition of EP1 antagonists prevented the PGE2-mediated downregulation of AQP2. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus
3 Our study shows that in mpkCCDc14 cells, reduced EP4 receptor and increased EP1/FP receptor expression by dDAVP explains the differential effects of PGE2 and PGF2alpha on AQP2 abundance with or without dDAVP. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus