Pub. Date : 2022
PMID : 35125086
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signaling. | nimbolide | aldo-keto reductase family 1 member B | Homo sapiens |
| 2 | Molecular docking and simulation, overexpression, and knockdown experiments were performed to determine whether nimbolide targets AR and IGF-1R. | nimbolide | aldo-keto reductase family 1 member B | Homo sapiens |
| 3 | RESULTS: Nimbolide inhibited AR with consequent blockade of the IGF-1/PI3K/Akt and HIF-1 /VEGF signaling circuit by influencing the phosphorylation and intracellular localisation of key signaling molecules. | nimbolide | aldo-keto reductase family 1 member B | Homo sapiens |
| 4 | Downregulation of DNMT-1, HDAC-6, miR-21, HOTAIR, and H19 with upregulation of miR-148a/miR-152 indicated that nimbolide regulates AR and IGF-1/PI3K/Akt signaling via epigenetic modifications. | nimbolide | aldo-keto reductase family 1 member B | Homo sapiens |
| 5 | Coadministration of nimbolide with metformin and the chemotherapeutic drugs tamoxifen/cisplatin displayed higher efficacy than single agents in inhibiting IGF-1/PI3K/Akt/AR signaling. | nimbolide | aldo-keto reductase family 1 member B | Homo sapiens |