Title : Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.

Pub. Date : 2022 Feb 3

PMID : 35016033






1 Functional Relationships(s)
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1 Mechanistically, IFN-gamma and/or LPS stimulation promotes signal transducers and activators of transcription 1 (STAT1)-mediated ASS1 transcription and Janus kinase2 (JAK2)-mediated phosphorylation of ASS1 at tyrosine 87, thereby leading to citrulline depletion. Tyrosine signal transducer and activator of transcription 1 Homo sapiens