Title : Circadian transcription factor NPAS2 and the NAD+ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward.

Pub. Date : 2022 Feb

PMID : 35001440






5 Functional Relationships(s)
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1 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD sirtuin 1 Mus musculus
2 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD sirtuin 1 Mus musculus
3 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD sirtuin 1 Mus musculus
4 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD sirtuin 1 Mus musculus
5 In the nucleus accumbens (NAc), a region important for reward, both SIRT1 and the circadian transcription factor neuronal PAS domain protein 2 (NPAS2) are highly enriched, and both are regulated by the metabolic cofactor NAD+. NAD sirtuin 1 Mus musculus