Title : PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer's Diseases.

Pub. Date : 2022 Jan 19

PMID : 34965724






4 Functional Relationships(s)
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1 PPAR-alpha Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer"s Diseases. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 In this study, we examined the ameliorative effect and the mechanisms of a PPAR-alpha agonist, GW7647, on the established AD models using APP/PS1 mice and APPsw/SH-SY5Y cells. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
3 Our data suggested that activation of PPAR-alpha by GW7647 improved the disruption of iron homeostasis in the brain of APP/PS1 mice and alleviated neuronal inflammation and lipid peroxidation, which was possibly related to the upregulated transcription of GPx4 mediated by the interaction of GPx4 noncoding region and the PPAR-alpha. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
4 Our data suggested that activation of PPAR-alpha by GW7647 improved the disruption of iron homeostasis in the brain of APP/PS1 mice and alleviated neuronal inflammation and lipid peroxidation, which was possibly related to the upregulated transcription of GPx4 mediated by the interaction of GPx4 noncoding region and the PPAR-alpha. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus