Title : Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.

Pub. Date : 2021 Dec 17

PMID : 34934919






1 Functional Relationships(s)
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1 By modulating lactate metabolism, ITV induced the concomitant acidification of the intra- and extracellular environment, which synergistically suppressed S6K1 activity in cancer cells through protein phosphatase-2A-mediated dephosphorylation via G-protein-coupled receptor(s). Lactic Acid ribosomal protein S6 kinase B1 Homo sapiens