Pub. Date : 2021 Dec 20
PMID : 34928817
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway. | NAD | sirtuin 1 | Mus musculus |
| 2 | OBJECTIVE: To investigate the effect of NAD+ on thymus autophagy in experimental autoimmune encephalomyelitis (EAE) mice through SIRT1. | NAD | sirtuin 1 | Mus musculus |
| 3 | RESULTS: Enrichment analysis showed PI3K-Akt-mTOR and autophagy pathway were main terms in EAE diseases, and the relationship between NAD+ and SIRT1. | NAD | sirtuin 1 | Mus musculus |
| 4 | The activation of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group consistent with decreased P62, Beclin1, LC-3A/B and SIRT1, and NAD+ reversed these results, furthermore SIRT1 inhibitor: SIRT-IN3 weakened the NAD+" effects in both in vivo and in vitro experiments. | NAD | sirtuin 1 | Mus musculus |
| 5 | The activation of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group consistent with decreased P62, Beclin1, LC-3A/B and SIRT1, and NAD+ reversed these results, furthermore SIRT1 inhibitor: SIRT-IN3 weakened the NAD+" effects in both in vivo and in vitro experiments. | NAD | sirtuin 1 | Mus musculus |
| 6 | CONCLUSIONS: NAD+ exerted a protective effect on EAE mice by inhibiting PI3K/Akt/mTOR signaling pathway through SIRT1 in TECs, and prevented EAE mice from sustained damage. | NAD | sirtuin 1 | Mus musculus |