Title : Influence of anti-TNF therapy and homocysteine level on carotid intima-media thickness in rheumatoid arthritis patients.

Pub. Date : 2022 Jan

PMID : 34917185






2 Functional Relationships(s)
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1 Elevated levels of tumor necrosis factor alpha (TNF-alpha), a major pro-inflammatory cytokine, are involved in endothelial cell activation of medium and large arteries, leading to increased endothelial permeability, generation of superoxide anion radical and hydrogen peroxide, and decreased availability of nitric oxide (NO). Superoxides tumor necrosis factor Homo sapiens
2 Elevated levels of tumor necrosis factor alpha (TNF-alpha), a major pro-inflammatory cytokine, are involved in endothelial cell activation of medium and large arteries, leading to increased endothelial permeability, generation of superoxide anion radical and hydrogen peroxide, and decreased availability of nitric oxide (NO). Superoxides tumor necrosis factor Homo sapiens