Title : Combination of sodium butyrate and probiotics ameliorates severe burn-induced intestinal injury by inhibiting oxidative stress and inflammatory response.

Pub. Date : 2021 Nov 16

PMID : 34903409






3 Functional Relationships(s)
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1 In addition, this study showed that combined NaB and PROB administration increased nuclear factor-erythroid 2-related factor 2 (Nrf2) protein expression and decreased the phosphorylation of nuclear factor (NF)-kappaB and extracellular signal-regulated kinase 1/2 (ERK 1/2). nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 In addition, this study showed that combined NaB and PROB administration increased nuclear factor-erythroid 2-related factor 2 (Nrf2) protein expression and decreased the phosphorylation of nuclear factor (NF)-kappaB and extracellular signal-regulated kinase 1/2 (ERK 1/2). nab NFE2 like bZIP transcription factor 2 Rattus norvegicus
3 In conclusion, our findings indicate that combined NaB and PROB treatment may inhibit severe burn-induced inflammation and oxidative stress in the small intestine by regulating HMGB1/NF-kappaB and ERK1/2/Nrf2 signaling, thereby providing a new therapeutic strategy for intestinal injury induced by severe burn. nab NFE2 like bZIP transcription factor 2 Rattus norvegicus