Title : cAMP-Mediated Autophagy Promotes Cell Survival via ROS-Induced Activation of PARP1: Implications for Treatment of Acute Lymphoblastic Leukemia.

Pub. Date : 2022 Mar 1

PMID : 34880123






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, we reveal that cAMP-mediated PARP1-activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 Furthermore, we reveal that cAMP-mediated PARP1-activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
3 Implications: PARP1 inhibitors augment the DNA damage-induced killing of ALL cells by limiting the opposing effects of cAMP-mediated autophagy, which involves ROS-induced PARP1-activation and depletion of cellular NAD-levels. NAD poly(ADP-ribose) polymerase 1 Homo sapiens