Title : A buried glutamate in the cross-β core renders β-endorphin fibrils reversible.

Pub. Date : 2021 Dec 2

PMID : 34812835






2 Functional Relationships(s)
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1 A buried glutamate in the cross-beta core renders beta-endorphin fibrils reversible. Glutamic Acid proopiomelanocortin Homo sapiens
2 Here, we investigate the critical role of a buried glutamate, Glu8, in the pH-responsive disassembly of beta-endorphin fibrils using all-atom molecular dynamics simulations along with structure-based pKa prediction. Glutamic Acid proopiomelanocortin Homo sapiens