Title : NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells.

Pub. Date : 2021 Dec

PMID : 34806016






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Supplementation with the NAD+ precursor dihydronicotinamide riboside (NRH) rapidly increased NAD+ levels in GSCs and glioma cells, inducing PARP1 activation and mild suppression of replication fork progression. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 Supplementation with the NAD+ precursor dihydronicotinamide riboside (NRH) rapidly increased NAD+ levels in GSCs and glioma cells, inducing PARP1 activation and mild suppression of replication fork progression. NAD poly(ADP-ribose) polymerase 1 Homo sapiens