Title : IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1.

Pub. Date : 2021 Nov 5

PMID : 34769439






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In addition, IL-4 and IL-13 stimulate tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1). Tyrosine insulin receptor substrate 1 Mus musculus
2 In addition, IL-4 and IL-13 stimulate tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1). Tyrosine insulin receptor substrate 1 Mus musculus
3 Prolonged treatment with these cytokines leads to increased IRS-1 abundance, which, in turn, amplifies IL-4- and IL-13-stimulated IRS-1 tyrosine phosphorylation. Tyrosine insulin receptor substrate 1 Mus musculus
4 Prolonged treatment with these cytokines leads to increased IRS-1 abundance, which, in turn, amplifies IL-4- and IL-13-stimulated IRS-1 tyrosine phosphorylation. Tyrosine insulin receptor substrate 1 Mus musculus
5 Through signaling crosstalk between IL-4/IL-13 and insulin, a hormone routinely included in mammary cultures, IRS-1 tyrosine phosphorylation is further enhanced. Tyrosine insulin receptor substrate 1 Mus musculus