Title : Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction.

Pub. Date : 2021 Dec

PMID : 34768108






1 Functional Relationships(s)
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1 Using the FDA-approved CG compound Lanatoside C (LanC) and human pancreatic cancer cell lines as model systems, we discovered that LanC preferably suppressed ER stress induction of GRP78 and to a lesser extent GRP94. lanatoside C heat shock protein 90 beta family member 1 Homo sapiens