Title : Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.

Pub. Date : 2021 Oct 8

PMID : 34661070






1 Functional Relationships(s)
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1 The classification process revealed that the similarity in Galpha/Gbetagamma, but not in beta-arrestin (betaarr), responses was correlated with the potential of Met-ENK, deltorphin II, (d-penicillamine2,5)-enkephalin (DPDPE), ARM390, and SNC-80 to enhance cAMP production, all of which required Ca2+ mobilization to produce this response. Cyclic AMP proopiomelanocortin Homo sapiens