Title : Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications.

Pub. Date : 2022 Feb

PMID : 34647621






3 Functional Relationships(s)
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1 Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Mechanistic studies revealed increased phosphorylation of STAT3 in nicotine-treated macrophages that was mediated through Src activation. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 Importantly, pretreatment of macrophages with either Src or STAT3 inhibitor abrogated nicotine-induced macrophage polarization, growth, and motility, suggesting a functional role of the Src-STAT3 signaling axis. Nicotine signal transducer and activator of transcription 3 Homo sapiens