Title : Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy.

Pub. Date : 2021 Oct 3

PMID : 34638458






3 Functional Relationships(s)
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Protein Name
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1 Both, classical NAD-like and non-NAD-like PARP-1 inhibitors reduced viability and clonogenic potential of ccRCC cell lines and suppressed growth of ccRCC xenograft tumors. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 However, classical NAD-like PARP-1 inhibitors affected viability of normal kidney epithelial cells at high concentrations, while novel non-NAD-like PARP-1 inhibitors exhibited activity against malignant cells only. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
3 However, classical NAD-like PARP-1 inhibitors affected viability of normal kidney epithelial cells at high concentrations, while novel non-NAD-like PARP-1 inhibitors exhibited activity against malignant cells only. NAD poly(ADP-ribose) polymerase 1 Homo sapiens