Title : Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A.

Pub. Date : 2021 Aug 29

PMID : 34564613






5 Functional Relationships(s)
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1 Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A. Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
2 Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
3 It was thought that the hydroxyl group at position 3 of the galloyl group in the EGCG was responsible for binding to SEA and suppressing SEA-induced phosphorylation of STAT3. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
4 Through protein thermal shift assay in vitro, the binding of the gp130 receptor to SEA and the phosphorylation of STAT3 were inhibited by the interaction between EGCG and SEA. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
5 As far as we know, this is the first report to document that EGCG inhibits the binding of the gp130 receptor to SEA and the associated phosphorylation of STAT3. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus