Title : Increased lipogenesis is critical for self-renewal and growth of breast cancer stem cells: Impact of omega-3 fatty acids.

Pub. Date : 2021 Dec

PMID : 34486791






2 Functional Relationships(s)
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1 Here, by using the in vitro BCSC models, mammosphere-derived MCF-7 cells and HMLE-Twist-ER cells, we found that the cells with stem cell-like properties exhibited a very distinct profile of fatty acid metabolism compared with that of their parental cancer cells, characterized by increased lipogenesis, especially the activity of stearoyl-CoA desaturase 1 (SCD1) responsible for the production of monounsaturated fatty acids (MUFA), and augmented synthesis and utilization of the omega-6 arachidonic acid (AA). Fatty Acids stearoyl-CoA desaturase Homo sapiens
2 Here, by using the in vitro BCSC models, mammosphere-derived MCF-7 cells and HMLE-Twist-ER cells, we found that the cells with stem cell-like properties exhibited a very distinct profile of fatty acid metabolism compared with that of their parental cancer cells, characterized by increased lipogenesis, especially the activity of stearoyl-CoA desaturase 1 (SCD1) responsible for the production of monounsaturated fatty acids (MUFA), and augmented synthesis and utilization of the omega-6 arachidonic acid (AA). Fatty Acids stearoyl-CoA desaturase Homo sapiens