Title : 6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity.

Pub. Date : 2021 Sep

PMID : 34420370






1 Functional Relationships(s)
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1 These data suggest that 6beta-hydroxytestosterone promotes angiotensin II-induced increase in systolic blood pressure and associated pathogenesis via cPLA2alpha activation and generation of eicosanoids, most likely prostaglandin E2 and thromboxane A2 that exerts prohypertensive effects by stimulating EP1/EP3 and TP receptors, respectively. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus