Title : Discovery of a Carbamoyl Phosphate Synthetase 1-Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis.

Pub. Date : 2021 Dec

PMID : 34343359






1 Functional Relationships(s)
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1 LC-MS assay and Seahorse analysis revealed that UC dysregulation(UCD) led to the deceleration of the tricarboxylic acid(TCA) cycle, while excess ammonia caused by CPS1 deficiency activated fatty acid beta-oxidation(FAO) through p-AMPK. Fatty Acids protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens