Title : CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3.

Pub. Date : 2022 Feb

PMID : 34310951






1 Functional Relationships(s)
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1 We further show that CLEC12B recruits SHP2 phosphatase through its immunoreceptor tyrosine-based inhibition motif domain, inactivates signal transducer and activator of transcription 1/3/5, increases p53/p21/p27 expression/activity, and modulates melanoma cell proliferation. Tyrosine signal transducer and activator of transcription 1 Homo sapiens